Mark A. Smith
Contents |
Mark A. Smith, Ph.D.
Case Western Reserve University
Department of Pathology
2103 Cornell Road, WRB 5101
Cleveland, OH 44106
Phone: (216) 368-3670
Fax: (216) 368-8964
Email: mark.smith@case.edu
Webpage: [1]
[edit] Faculty Appointments
Professor, Department of Pathology
[edit] Academic History
1986 B.Sc. (Honors), Molecular Biology & Biochemistry, Durham University, England
1986-1990 Ph.D., Biochemistry, Nottingham University, England
1990-1991 Postdoctoral Biochemist, Department of Immunodermatology, Sandoz Forschungsinstitut, Vienna, Austria
1991-1992 Karl Landsteiner, Research Fellow, Sandoz Forschungsinstitut, Vienna, Austria
1992-1994 Research Associate, Case Western Reserve University, Cleveland, Ohio, USA
[edit] Positions and Employment
1994-1995 Instructor, Case Western Reserve University, Cleveland, Ohio, USA
1995-1999 Assistant Professor, Case Western Reserve University, Cleveland, Ohio, USA
1999-2002 Associate Professor, Case Western Reserve University, Cleveland, Ohio, USA
2001-present Affiliate Associate Professor/Professor, Department of Chemistry and Biochemistry, University of Alaska, Fairbanks, Fairbanks, Alaska, USA
2002-present Professor, Case Western Reserve University, Cleveland, Ohio, USA
[edit] Honors and Awards
1986-1989 Science and Education Research Council Studentship
1991-1992 Karl Landsteiner Research Fellowship
1995 AFAR Award for Biomedical Research
1995, 1996* Ruth Salta Junior Investigator Achievement Award, American Health Assistance Foundation (AHAF) [*Only two-time awardee]
1995-1997 American Philosophical Society Fellowship
1997 Center for Professional Ethics Fellowship
1997 Young Scientist Lectureship Award, International Society for Neurochemistry
1997 Nathan Shock New Investigator Award, The Gerontological Society of America
1998 CWRU Nominee for the Pew Scholars Program in the Biomedical Sciences
1999 Zenith Award, Alzheimer’s Association
2000 Jordi Folch-Pi Award, American Society for Neurochemistry
2000 Stephanie B. Overstreet Scholar, Alzheimer’s Association
2002 Hermann-Esterbauer Award, HNE Society
2003 Student Mentor Award, Catalyst Program, Gilmour Academy
2004 Outstanding Mentor Award, School of Graduate Studies/Office of Postdoctoral Affairs/Postdoctoral Researcher’s Association, Case Western Reserve University
2004 Community Service Award, Cleveland Area Chapter of the Alzheimer’s Association
2005 Fellow, American Aging Association
2007 Mentor Award, Senior’s Salute, Case Western Reserve University
2008 Denham Harman Research Award, American Aging Association
[edit] Research
The focus of Dr. Smith’s research involves investigating the pathological mechanism(s) underlying selective neuronal death in neurodegenerative diseases such as Alzheimer’s disease. Dr. Smith’s research involves a variety of techniques ranging from histological to molecular biology to cellular models and encompasses diagnostic, mechanistic, and therapeutic strategies. Current projects are directed towards 1) fundamental metabolic alterations; 2) homeostatic dysregulation of transition metals; 3) signal transduction alterations; and 4) inappropriate re-entry into the cell cycle.
Dr. Smith has authored over 600 peer-reviewed manuscripts and chapters and is recognized as one of the top cited researchers in the fields of Neuroscience & Behavior, Alzheimer Disease and Free Radical Biology.
[edit] Recent Publications
• Evans, T., Siedlak, S.L., Lu, L., Fu, X., Wang, Z., McGinnis, W.R., Fakhoury, E., Castellani, R.J., Hazen, S.L., Walsh, W.J., Lewis, A.T., Salomon, R.G., Smith, M.A., Perry, G. and Zhu, X. (2008) The autistic phenotype exhibits a remarkably localized modification of brain protein by products of free radical-induced lipid oxidation. Am. J. Biochem. Biotechnol., 4, 61-72.
• Thakur, A., Siedlak, S.L., James, S.L., Bonda, D.J., Rao, A., Webber, K.M., Camins, A., Pallàs, M., Casadesus, G., Lee, H.G., Bowser, R., Raina, A.K., Perry, G., Smith, M.A. and Zhu, X. (2008) Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. Int. J. Clin. Exp. Pathol., 1, 134-146.
• Mondragón-Rodríguez, S., Mena, R., Binder, L.I., Smith, M.A., Perry, G. and García-Sierra, F. (2008) Conformational changes and cleavage of tau in Pick bodies parallels the early processing of tau found in Alzheimer pathology. Neuropathol. Appl. Neurobiol., 34, 62-75.
• Pelegri, C., Canudas, A.M., Del Valle, J., Casadesus, G., Smith, M.A., Camins, A., Pallás, M. and Vilaplana, J. (2008) Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mech. Ageing Dev., in press.
• Collingwood, J.F., Dunin-Borkowski, R., Siedlak, S.L., Perry, G., Smith, M.A. and Dobson, J. (2008) Three-dimensional electron tomographic imaging and characterization of iron compounds within Alzheimer’s plaque fragments. J. Alzheimers Dis., in press.
• Zhu, X., Siedlak, S.L., Harris, P.L.R., Perry, G., Richardson, S.L., Castellani, R.J., Cohen, M.L. and Smith, M.A. (2008) Neuronal binucleation in adult human hippocampus. Neuropathol. Appl. Neurobiol., in press.
• Mondragón-Rodríguez, S., Basurto-Islas, G., Santa Maria, I., Mena, R., Binder, L.I., Avila, J., Smith, M.A., Perry, G. and García-Sierra, F. (2008) Cleavage and conformational changes of tau protein follows phosphorylation during Alzheimer’s disease. Int. J. Exp. Pathol., 89, 81-90.
• Gonzalez-Cuyar, L.F., Perry, G., Miyajama, S., Atwood, C.S., Riveros-Angel, M., Lyons, P.F., Siedlak, S.L., Perry, G., Smith, M.A. and Castellani, R.J. (2008) Redox active iron accumulation in aceruloplasminemia. Neuropathology, in press.
• Tamagno, E., Guglielmotto, M., Aragno, M., Borghi, R., Autelli, R., Giliberto, L., Muraca, G., Danni, O., Zhu, X., Smith, M.A., Perry, G., Jo, D.-G., Mattson, M.P. and Tabaton, M. (2008) Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein. J. Neurochem., 104, 683-695.
• Su, B., Wang, X., Drew, K., Smith, M.A., Perry, G. and Zhu, X. (2008) Physiological regulation of tau phosphorylation during hibernation. J. Neurochem., in press.
• Gelfand, S.L., Vento, M., Sastre, J., Lust, W.D., Smith, M.A., Perry, G., Walsh, M. and Martin, R. (2008) A novel rat pup model of asphyxia and resuscitation. Neonatalogy, in press.
• Myung, N.H., Lee, H.G., Kruman, I.I., Siedlak, S.L., Perry, G. and Smith, M.A. (2008) Evidence of DNA damage in Alzheimer disease: phosphorylation of the histone H2A.X in astrocytes. AGE, in press.
• Perry, G., Zhu, X., Babar, A.K., Siedlak, S.L., Yang, Q., Ito, G., Iwatsubo, T., Smith, M.A. and Chen, S.G. (2008) Leucine-rich repeat kinase 2 colocalizes with α-synuclein in Parkinson’s disease, but not tau-containing deposits in tauopathies. Neurodegenerative Dis., 5, 222-224.
• Bajic, V., Spremo-Potparevic, B., Zivkovic, L. and Smith, M.A. (2008) Altered temporal dynamics of centromeres in Alzheimer’s disease: a pathway to neuronal cell death? Biosci Hypotheses, in press.
• Tajes, M., Folch, J., Ferrer, I., Gutierrez-Guesta, J., Caballero, B., Smith, M.A., Casadesus, G., Camins, A. And Pallàs, M. (2008) Lithium treatment prevents tau kinases activity in a murine model of senescence. J. Neuropathol. Exp. Neurol., in press.
• Pizarro, J.G., Yeste-Velasco, M., Rimbau, V., Casadesús, G., Smith, M.A., Pallàs, M., Folch, J. and Camins, A. (2008) Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Int. J. Devl. Neurosci., 26, 269-276.
• Wang, X., Su, B., Harris, P.L.R., Fujioka, H., Perry, G., Smith, M.A. and Zhu, X. (2008) DLP1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer disease patients. Am. J. Pathol., in press.