Contents 1 Case 19: Cholesterol & Atherosclerosis 1.1 1. List the major steps in the biosynthesis of cholesterol, emphasizing the regulation of this process. 1.2 2. List the processes that lead to cholesterol turnover or elimination from the body. 1.3 3. Describe the synthesis and secretion of bile acids and explain the importance of these compounds in cholesterol turnover. 1.4 4. List the major lipoproteins that are important in cholesterol transport and describe the role of each lipoprotein. 1.5 5. Explain the role of oxidized LDL and foam cells in the formation of atherosclerotic plaque. 1.6 6. Describe the major therapies used to lower blood cholesterol and explain the mechanism of action in each one. 1.7 7. Understand the currently accepted guidelines for assessing risk for coronary heart disease and explain how this risk assessment is used to choose therapies to lower blood cholesterol.

[edit] Case 19: Cholesterol & Atherosclerosis

[edit] 1. List the major steps in the biosynthesis of cholesterol, emphasizing the regulation of this process.

[edit] 2. List the processes that lead to cholesterol turnover or elimination from the body.

[edit] 3. Describe the synthesis and secretion of bile acids and explain the importance of these compounds in cholesterol turnover.

[edit] 4. List the major lipoproteins that are important in cholesterol transport and describe the role of each lipoprotein.

[edit] 5. Explain the role of oxidized LDL and foam cells in the formation of atherosclerotic plaque.

[edit] 6. Describe the major therapies used to lower blood cholesterol and explain the mechanism of action in each one.

[edit] 7. Understand the currently accepted guidelines for assessing risk for coronary heart disease and explain how this risk assessment is used to choose therapies to lower blood cholesterol.