Contents 1 Case 16: Purine Metabolism & Gout 1.1 1. To be determined. 1.2 2. Describe nucleotide nomenclature and recognize the major purine and pyrimidine bases 1.3 3. Explain the salvage pathways of purine nucleotide synthesis 1.4 4. Discuss the strategy, regulation and components of the purine nucleotide biosynthetic pathways 1.5 5. List the two salvage enzymes that salvage purines, APRT and HGPRT, and explain their substrate specificities and regulation 1.6 6. Describe the consequences of hyperuricemia in causing gout 1.7 7. List the agents used to treat gout and explain the mechanism of action of each

[edit] Case 16: Purine Metabolism & Gout

[edit] 1. To be determined.

[edit] 2. Describe nucleotide nomenclature and recognize the major purine and pyrimidine bases

[edit] 3. Explain the salvage pathways of purine nucleotide synthesis

[edit] 4. Discuss the strategy, regulation and components of the purine nucleotide biosynthetic pathways

[edit] 5. List the two salvage enzymes that salvage purines, APRT and HGPRT, and explain their substrate specificities and regulation

[edit] 6. Describe the consequences of hyperuricemia in causing gout

[edit] 7. List the agents used to treat gout and explain the mechanism of action of each

8. Describe the role of uricosuric agents in the treatment of gout