Contents 1 Case 11: Liver & Ethanol 1.1 1. Trace the pathways of alcohol metabolism in the liver and explain the affect of ethanol metabolism on the TCA cycle and the pathways of fatty acid metabolism and gluconeogenesis. 1.2 2. List the amount of alcohol necessary to cause Alcohol Liver Disease. 1.3 3. Use the CAGE questions to identify/diagnose if alcohol consumption is a problem in a patient. 1.4 4. List the two scoring systems to define the prognosis of Alcohol Liver Disease and name the cofactors that contribute to liver disease in alcoholics. 1.5 5. Describe the current inflammatory hypothesis of liver injury by chronic alcohol consumption. 1.6 6. Describe the histopathology of alcoholic liver disease. 1.7 7. Explain how alcohol may potentiate acetaminophen toxicity in the liver. 1.8 8. List the pharmacologic treatment for severe alcoholic hepatitis. 1.9 9. Compare and contrast the effects of binge drinking versus heavy regular intake of ethanol. 1.10 10. List the behavioral and pharmacologic therapies used to treat alcohol addiction.

[edit] Case 11: Liver & Ethanol

[edit] 1. Trace the pathways of alcohol metabolism in the liver and explain the affect of ethanol metabolism on the TCA cycle and the pathways of fatty acid metabolism and gluconeogenesis.

[edit] 2. List the amount of alcohol necessary to cause Alcohol Liver Disease.

[edit] 3. Use the CAGE questions to identify/diagnose if alcohol consumption is a problem in a patient.

[edit] 4. List the two scoring systems to define the prognosis of Alcohol Liver Disease and name the cofactors that contribute to liver disease in alcoholics.

[edit] 5. Describe the current inflammatory hypothesis of liver injury by chronic alcohol consumption.

[edit] 6. Describe the histopathology of alcoholic liver disease.

[edit] 7. Explain how alcohol may potentiate acetaminophen toxicity in the liver.

[edit] 8. List the pharmacologic treatment for severe alcoholic hepatitis.

[edit] 9. Compare and contrast the effects of binge drinking versus heavy regular intake of ethanol.

[edit] 10. List the behavioral and pharmacologic therapies used to treat alcohol addiction.